Brain Diseases

Global Experts Meeting on Frontiers in Alzheimer’s Disease & Dementia

Rome, Italy during Oct-14-16, 2019.

Session: Brain Diseases

Brain diseases occur in various forms of infection, trauma, stroke, convulsions, and tumors are some of the main categories of brain diseases. Here's an overview of various brain diseases.

• Migraine
• Attention deficit hyperactivity disorder
• Motor neuron disease
• Bipolar disorder
• Arteriovenous malformation.
• Encephalitis
• Seizures
• Stroke
• Psychological trauma
• Brain abscess

Submit your abstract on your interested session.

Register now on an appropriate package of your interest.

Dementia Care and Consulting

Global Experts Meeting on Frontiers in Alzheimer’s Disease & Dementia

Rome, Italy during Oct-14-16, 2019.

Session: Dementia Care and Consulting

The care of a dementia person influences different people in different ways. At all events, care can also be physically and rationally weakening. It influences all aspects of your life and can make you feel separated, pushed and even discouraged at times. You may also have your own physical and psychological well - being needs, which you and others may neglect when you look after someone else. There are many positive things to look after. These incorporate the adaptation of new skills, the expansion of existing skills, the strengthening of connections, a sense of pride in what you are doing and the support of someone who is imperative to you. In addition, because a man has dementia, it does not mean that there are no great circumstances to share with you.

• Dealing with Dementia Behaviour
• Dementia Risk and Preventions
• Dementia Awareness

Submit your abstract on your interested session.

Register now on an appropriate package of your interest.

Alzheimer’s Clinical Trials and Studies

Global Experts Meeting on Frontiers in Alzheimer’s Disease & Dementia

Rome, Italy during Oct-14-16, 2019.

Session: Alzheimer’s Clinical Trials and Studies

Clinical studies are asked about examinations in which people decide whether medicines are protected and feasible. There can be no better medicines, no counteractive action and no cure for Alzheimer's disease without clinical research and the assistance of human volunteers.

Clinical studies are sometimes referred to as clinical examinations; the terms are often used in reciprocal terms, but there are unobtrusive contrasts. Clinical studies test new intercessions or drugs to prevent, detect or treat infections. A clinical report is any kind of clinical research, including individuals, which pays little attention to whether or not they try to intercede. Clinical examinations can likewise take a gander at different parts of care, for example, enhancing personal satisfaction.

Submit your abstract on your interested session.

Register now on an appropriate package of your interest.

Vascular Dementia

Global Experts Meeting on Frontiers in Alzheimer’s Disease & Dementia

Rome, Italy during Oct-14-16, 2019.

Session: Vascular Dementia

Vascular dementia otherwise referred to as multi-infarct dementia, is the second most fundamental cause of dementia in more experienced persons. Since it has a lower profile than Alzheimer's, many people do not speculate that vascular dementia is noticeably dangerous when neglect occurs. It is also difficult to analyze, so it is difficult to know exactly how many people experience the ill effects of vascular dementia. Current assessments account for 15% to 20% of cases of dementia in more established adults with vascular dementia. Vascular dementia occurs when blood supplying vessels to the brain are significantly blocked or limited. Strokes occur when the blood supply that transmits oxygen to the mind is suddenly cut. However, not all people with a stroke develop vascular dementia. Vascular dementia may occur as " noiseless " strokes heap up after some time. Vascular dementia often attracts attention just when the effect of so many strokes means a notable handicap. Staying away from and controlling hazardous factors such as diabetes, hypertension, smoking and high cholesterol can help to control the risk of vascular dementia.

Submit your abstract on your interested session.

Register now on an appropriate package of your interest.

Neurodegenerative Diseases

Neurodegenerative diseases consist of a wide range of disorders characterized by nerve cell progressive degeneration or death. It affects the nervous tissue and also causes various neuropsychological effects. This is a term for a variety of conditions that affect neurons in the human brain in particular.

The development of neurodegenerative diseases has demonstrated that genetic and environmental factors play an important role. Age is one of the main risk factors common to all types of neurodegenerative disease as it commonly progresses in older age.

• Cognition
• Multiple Sclerosis
• Parkinson's disease
• Huntington's disease
• Neurovascular Dysfunction and Neurodegeneration

For abstract submission under the session PS:

 https://frontiersmeetings.com/conferences/dementia/Neurodegenerative-Diseases

Alzheimer’s Disease Pathophysiology and Disease Mechanisms

Alzheimer's disease is progressive dementia with neuron loss and two major neuropathological microscopic characteristics: extracellular amyloid plaques and intracellular neurofibrillary tangles. Early-onset of AD, a rare family form, is caused by one of three genes mutating: (amyloid precursor protein), (presenilin 2) or (presenilin 1). The sporadic form usually occurs after 65 years of age and is accountable in most cases; it most likely results from a combination of genetic and influence of environment. The age and presence of the E4 allele (Apolipoprotein E) are confirmed risk factors for sporadic AD. Amyloid plaques consist mainly of neurotoxic peptide amyloid (A?, Abeta), sequentially cleaved by two enzymes from a larger precursor protein (APP): ?-secretase (also referred to as BACE1) and ?-secretase (composed of four proteins, one of which is preseniline). If APP is cleaved by the ?-secretase enzyme instead of ?-secretase, A? is not formed.  Neurofibrillary tangles mainly consist of the protein tau that binds to microtubules and facilitates the neuronal transport system. Tau disassembly from microtubules and aggregation into tangles prevents transport and leads to microtubule disassembly. Tau phosphorylation could play an important role in this. The current rational pharmacological treatment is based on the selective vulnerability of neuronal systems, such as cholinergic, serotonergic and noradrenergic and glutamatergic systems.

This session includes Aging, Prions and Alzheimer’s disease, Cellular signaling and cell to cell transmission, Oxidative damage and mitochondrial dysfunction, Autoimmunity in Alzheimer’s, Blood-brain barrier, transport, Neurogenesis, stem cells, and Cell death.

For abstract submission under the session, please visit: 

https://frontiersmeetings.com/conferences/dementia/Alzheimers-Disease-Pathophysiology-and-Disease-Mechanisms

Alzheimer’s Disease Diagnosis and Symptoms

Alzheimer's is caused by the death of brain cells. It is a neurological disorder in which brain cell death leads to a loss of memory and a cognitive decline. The total brain shrinks in Alzheimer's, nerve cells and tissue connections that cannot be seen or tested in the living brain affected by Alzheimer's disease, post - mortem / autopsy always shows small inclusions in nerve tissues called plaques and tangles. Plaques are found between dying cells in the brain from the development of the beta-amyloid (amyloid plaques) protein.

Diagnosis: AD is typically diagnosed after healthcare providers perform tests and look at health history to help determine whether a person's memory problems or other mental skills are declining over time. Your doctor may:

• Ask about your medical history, your ability to carry out routine tasks, and changes in your behavior or personality.
• Perform tests to assess your memory, problem-solving, attention, counting, and language skills.
• Order medical tests to check your urine, blood, and spinal fluid.
• Conduct brain scans, such as computed tomography (CT) scan or magnetic resonance imaging (MRI) test.

Symptoms:

• Inability to communicate
• Inability to recognize oneself or family
• Weight loss
• Difficulty swallowing
• Groaning or grunting
• Increased sleeping
• Lack of bowel and bladder control

For more details about the session PS: https://frontiersmeetings.com/conferences/dementia/Alzheimers-Disease-Diagnosis-and-Symptoms

Causes and Prevention of Alzheimer’s

Alzheimer's is caused by the death of brain cells. It is a neurological disorder in which brain cell death leads to a loss of memory and a cognitive decline. The total brain shrinks in Alzheimer's, nerve cells and tissue connections that cannot be seen or tested in the living brain affected by Alzheimer's disease, post - mortem / autopsy always shows small inclusions in nerve tissues called plaques and tangles. Plaques are found between dying cells in the brain from the development of the beta-amyloid (amyloid plaques) protein. In brain neurons, the tangles exist from the disintegration of the second protein called tau.

Worldwide, nearly 44 million people suffered from dementia or related disorders in 2015, past results showed that 35,66 million people lived with dementia worldwide in 2010, with numbers expected to almost double every twenty years, to 65,7 million in 2030 and 115,4 million in 2050. In 2010, 58% of the population with dementia lived in countries with low or moderate incomes, which is expected to increase to 63% by 2030 and 71% by 2050. This condition is anticipated to double by 2030 and quite triple by 2050 to 115 million.

In this track we can discuss:

Neurological changes in the brain, Amyloid protein, Genetic associations and susceptibility genes, Role of Apolipoprotein E, Brain trauma, Metabolic syndrome and Alzheimer’s disease, protein misfolding, aggregation and toxicity, Disease-causing mutations, Epidemiology and prevalence, Histone modification, DNA methylation, Alzheimer’s disease prevention.

Submit your abstract under the session: Causes and Prevention of Alzheimer’s 

https://frontiersmeetings.com/conferences/dementia/Causes-and-Prevention-of-Alzheimers

Childhood Trauma and Dementia

New research recommends there is a solid relationship between initial childhood trauma, for example, that accomplished by the stolen ages, and dementia. There is an extensive agreement that shows that childhood trauma is essentially linked to improving sorrow. There is a strong connection between a high introduction to early life stress and affliction, which involves people who were a part of the stolen ages, and the likelihood of dementia being determined at some point on the road. Psychological trauma is any psychological disorder that unexpectedly overpowers the ability to give an insignificant sense of well - being and integrative wholeness, to overpower nervousness or defenselessness or to create a continuous change in the psychic organization. Trauma to children may affect the mental and physical well - being in adulthood.

• Childhood Trauma and PTSD Symptoms
• Psychological Therapies
• Childhood trauma with cognitive function in healthy adults
• Post-traumatic stress disorder and Alzheimer’s disease

Submit your abstract under the session: Childhood Trauma and Dementia at 
https://frontiersmeetings.com/conferences/dementia/Childhood-Trauma-and-Dementia

Dementia Care Practice and Awareness

People with dementia have multiple psychological deficits, including each memory impairment, which affects the flexibility to find new information or to recall previously learned information, and one or more subsequent symptoms- aphasia, apraxia, agnosia or executive dysfunction- such that the psychological deficits have a negative effect on the social or activity function. Additionally, persons with dementia typically suffer from comorbid conditions that additional complicate care and impede best outcomes. Therefore, it is urgent to develop care methods for people with dementia, given this increasing prevalence and therefore the associated burden that dementia places not only on individuals but also on caregivers, relationships and therefore on the health care system 's resources. Conventional views on geriatric care typically depict a slow pace of care that is certain and less demanding than acute care. Care for the elderly, and especially for people with dementia, is usually complicated, unpredictable and unstable. This session includes education and training of medical professionals, care and quality of life, personal care, cognitive education, support and training for informal and professional careers, practical implementation of scientific knowledge, non - pharmacological interventions, functional food, art, music and lifestyle.

Submit your abstract under the session: Dementia Care Practice and Awareness at https://frontiersmeetings.com/conferences/dementia/Care-Practice-and-Awareness

Dementia

Dementia is the term used to describe the symptoms of several conditions affecting the brain. Dementia is the term used to describe the symptoms of a number of brain conditions. Alzheimer's disease is commonly seen, and other conditions include Parkinson's disease. Symptoms seen in early stages are changes in personality, withdrawal, loss of memory, confusion and apathy. Early diagnosis helps to ensure early treatment, assistance and planning. Medicines may help with certain dementia symptoms, but no permanent cure. The majority of people with dementia are over 65 years of age, the condition is not normal for everyone older. The incidence of dementia increases with age, but it is not because an older person develops it. Although only 1 in 4 people was diagnosed with Alzheimer's disease or dementia. Few more information about vascular dementia, Lewy body dementia, frontotemporal dementia, rare causes of dementia, Creutzfeldt - Jakob disease, cognitive impairment associated with HIV, mild cognitive impairment.

Submit your abstract under the session: Dementia at https://frontiersmeetings.com/conferences/dementia/Dementia

Glimses of Frontiers meetings

Alzheimer's conference: Best presentations

Best Oral/ Poster awards are to encourage students and recent graduates to present their original research which will be later published in the International Journals. All accepted abstracts will be presented at the poster sessions during the conference. Frontiers Meetings aims at setting a platform for all the budding scientists and researchers to present their real-time work and share their views and aspects related to the theme of the conference i.e. " Advancements and Breakthroughs in the Fields of Dementia & Alzheimer’s Research"

Rewards:

Best Oral Presentation: USD 699*

Judging Criteria

·         After each presentation, we will send you a feedback link for rating the presentation.

·         Your feedback is very essential for every speaker so please rate on the basis of their presentation.

·         We will record your IP Address, so please do not vote more than once.

·         Chair & Co-chair will even evaluate the speakers' enthusiasm towards their interest, and knowledge in the area of their research.

·         Your feedback will be sent to our Chair and Co-chair and the Chairperson(s) decision will be final and no clarification will be given.

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Best Poster Presentation: USD 399*

·         The judgment will be done by Sessions Chair.

·         When the competition is being conducted, each participant should be ready in front of his/her poster to answer all the questions from the judges.

·         Judges will even evaluate the student's enthusiasm towards their study, interest, and knowledge in the area of their research.

·         The judge’s decision will be final and no clarification will be given.

·         The winners will be announced at the closing ceremony of the conference.

·         The decision of the winner will be withdrawn if the winner/winners is/are not present at the time of the announcement.

Recent best oral and Poster award winners:

Best poster award presentation at @Neurology conference 2019, London

Best oral talk presentation award @Neurology 2019, London

Register today to compete for best presentation competitions @ https://frontiersmeetings.com/conferences/dementia/registration

Researchers Identify Virus and Two Types of Bacteria as Major Causes of Alzheimer’s

A worldwide team of senior scientists and clinicians have come together to produce an editorial which indicates that certain microbes – a specific virus and two specific types of bacteria – are major causes of Alzheimer’s Disease. Their paper, which has been published online in the highly regarded peer-reviewed journal, Journal of Alzheimer’s Disease, stresses the urgent need for further research – and more importantly, for clinical trials of anti-microbial and related agents to treat the disease

This major call for action is based on substantial published evidence into Alzheimer’s. The team’s landmark editorial summarises the abundant data implicating these microbes, but until now this work has been largely ignored or dismissed as controversial – despite the absence of evidence to the contrary. Therefore, proposals for the funding of clinical trials have been refused, despite the fact that over 400 unsuccessful clinical trials for Alzheimer’s based on other concepts were carried out over a recent 10-year period.

Opposition to the microbial concepts resembles the fierce resistance to studies some years ago which showed that viruses cause certain types of cancer, and that a bacterium causes stomach ulcers. Those concepts were ultimately proved valid, leading to successful clinical trials and the subsequent development of appropriate treatments.

Professor Douglas Kell of The University of Manchester’s School of Chemistry and Manchester Institute of Biotechnology is one of the editorial’s authors. He says that supposedly sterile red blood cells were seen to contain dormant microbes, which also has implications for blood transfusions.

“We are saying there is incontrovertible evidence that Alzheimer’s Disease has a dormant microbial component, and that this can be woken up by iron dysregulation. Removing this iron will slow down or prevent cognitive degeneration – we can’t keep ignoring all of the evidence,” Professor Douglas Kell said.

This major call for action is based on substantial published evidence into Alzheimer’s. Image is adapted from the University of Manchester press release.

Professor Resia Pretorius of the University of Pretoria, who worked with Douglas Kell on the editorial, said “The microbial presence in blood may also play a fundamental role as causative agent of systemic inflammation, which is a characteristic of Alzheimer’s disease – particularly, the bacterial cell wall component and endotoxin, lipopolysaccharide. Furthermore, there is ample evidence that this can cause neuro inflammation and amyloid-β plaque formation.”

The findings of this editorial could also have implications for the future treatment of Parkinson’s Disease, and other progressive neurological conditions.

ABOUT THIS ALZHEIMER’S DISEASE RESEARCH

Source: University of Manchester
Image Credit: The image is adapted from the University of Manchester press release.
Original Research: Full open-access editorial for “Microbes and Alzheimer’s Disease” by Itzhaki, Ruth F.; Lathe, Richard; Balin, Brian J.; Ball, Melvyn J.; Bearer, Elaine L.; Bullido, Maria J.; Carter, Chris; Clerici, Mario; Cosby, S. Louise; Field, Hugh; Fulop, Tamas; Grassi, Claudio; Griffin, W. Sue T.; Haas, Jürgen; Hudson, Alan P.; Kamer, Angela R.; Kell, Douglas B.; Licastro, Federico; Letenneur, Luc; Lövheim, Hugo; Mancuso, Roberta; Miklossy, Judith; Lagunas, Carola Otth; Palamara, Anna Teresa; Perry, George; Preston, Christopher; Pretorius, Etheresia; Strandberg, Timo; Tabet, Naji; Taylor-Robinson, Simon D.; and Whittum-Hudson, Judith A. in Journal of Alzheimer’s Disease. Published online March 8 2016 doi:10.3233/JAD-160152