Researchers Identify Virus and Two Types of Bacteria as Major Causes of Alzheimer’s

A worldwide team of senior scientists and clinicians have come together to produce an editorial which indicates that certain microbes – a specific virus and two specific types of bacteria – are major causes of Alzheimer’s Disease. Their paper, which has been published online in the highly regarded peer-reviewed journal, Journal of Alzheimer’s Disease, stresses the urgent need for further research – and more importantly, for clinical trials of anti-microbial and related agents to treat the disease

This major call for action is based on substantial published evidence into Alzheimer’s. The team’s landmark editorial summarises the abundant data implicating these microbes, but until now this work has been largely ignored or dismissed as controversial – despite the absence of evidence to the contrary. Therefore, proposals for the funding of clinical trials have been refused, despite the fact that over 400 unsuccessful clinical trials for Alzheimer’s based on other concepts were carried out over a recent 10-year period.

Opposition to the microbial concepts resembles the fierce resistance to studies some years ago which showed that viruses cause certain types of cancer, and that a bacterium causes stomach ulcers. Those concepts were ultimately proved valid, leading to successful clinical trials and the subsequent development of appropriate treatments.

Professor Douglas Kell of The University of Manchester’s School of Chemistry and Manchester Institute of Biotechnology is one of the editorial’s authors. He says that supposedly sterile red blood cells were seen to contain dormant microbes, which also has implications for blood transfusions.

“We are saying there is incontrovertible evidence that Alzheimer’s Disease has a dormant microbial component, and that this can be woken up by iron dysregulation. Removing this iron will slow down or prevent cognitive degeneration – we can’t keep ignoring all of the evidence,” Professor Douglas Kell said.

This major call for action is based on substantial published evidence into Alzheimer’s. Image is adapted from the University of Manchester press release.

Professor Resia Pretorius of the University of Pretoria, who worked with Douglas Kell on the editorial, said “The microbial presence in blood may also play a fundamental role as causative agent of systemic inflammation, which is a characteristic of Alzheimer’s disease – particularly, the bacterial cell wall component and endotoxin, lipopolysaccharide. Furthermore, there is ample evidence that this can cause neuro inflammation and amyloid-β plaque formation.”

The findings of this editorial could also have implications for the future treatment of Parkinson’s Disease, and other progressive neurological conditions.

ABOUT THIS ALZHEIMER’S DISEASE RESEARCH

Source: University of Manchester
Image Credit: The image is adapted from the University of Manchester press release.
Original Research: Full open-access editorial for “Microbes and Alzheimer’s Disease” by Itzhaki, Ruth F.; Lathe, Richard; Balin, Brian J.; Ball, Melvyn J.; Bearer, Elaine L.; Bullido, Maria J.; Carter, Chris; Clerici, Mario; Cosby, S. Louise; Field, Hugh; Fulop, Tamas; Grassi, Claudio; Griffin, W. Sue T.; Haas, Jürgen; Hudson, Alan P.; Kamer, Angela R.; Kell, Douglas B.; Licastro, Federico; Letenneur, Luc; Lövheim, Hugo; Mancuso, Roberta; Miklossy, Judith; Lagunas, Carola Otth; Palamara, Anna Teresa; Perry, George; Preston, Christopher; Pretorius, Etheresia; Strandberg, Timo; Tabet, Naji; Taylor-Robinson, Simon D.; and Whittum-Hudson, Judith A. in Journal of Alzheimer’s Disease. Published online March 8 2016 doi:10.3233/JAD-160152

Dementia 2019: Registration

Dementia 2019: Registration

On behalf Frontiers Meetings Ltd we would like to announce our upcoming conference on “Global Experts Meeting on Frontiers in Alzheimer’s Disease & Dementia” scheduled during October 14-16 | 2019, Rome, Italy.

Theme: Advancements and Breakthroughs in the Fields of Dementia & Alzheimer’s Research.

If anyone interested to attend and present their research or listen to our renowned scientists from all over the world. We welcome all participants from your organization. for more details: https://frontiersmeetings.com/conferences/dementia/registration

Registration Type	Early Bird Registration Aug 15th, 2019		Mid On Registration Sep 15th, 2019		Spot Registration Oct 14th, 2019
	Academic	Business	Academic	Business	Academic	Business
Speaker Registration	699	799	799	899	899	999
Delegate Registration	599	699	699	799	799	899
Student Delegate	399	499	499	599	599	699
Poster Presentation (Academic)	649	749	749	849	849	949
Poster Presentation (Student)	499	499	599	599	699	699
Young Research Forum (Student Oral)	549	549	599	599	649	649
Exhibitor ( Booth Size 3M x 3M)	1200	1200	1300	1300	1400	1400
Video Presentation	300	300	349	349	399	399
E-Poster	99	99	99	99	99	99

REGISTRATION INCLUDES

·         Access to all Scientific Sessions, Poster sessions, Exhibitions

·         Handbook & Conference Materials

·         Lunch, Tea/Coffee breaks during the conference days

·         Accredited Certificates from the Organizing Committee

·         Access to the attendees' email list (post-conference)

·         Wi-Fi in meeting rooms

POSTER PRESENTATION

·         Includes all mentioned registration features.

·         Poster will be designated with serial numbers and will be placed in the poster hall before one hour of the session start.

·         Each author will be provided with a 1-meter X 1-meter poster presenting area and mounting pins / stick-tape.

·         Participants are responsible for mounting their posters during the presentation and in removing them as soon as the session ends.

·         Best Poster awards will be announced during the closing ceremony of the conference.

DELEGATE REGISTRATION INCLUDES

·         Access to all Scientific Sessions, Poster sessions, Exhibitions

·         Breakfast, Lunch, Tea/coffee breaks during the conference days

·         Certificate Accreditation from the Organizing Committee

·         Delegates are not allowed to present their papers in Oral or Poster sessions.

ACADEMIC REGISTRATION

·         Complimentary Lunch

·         Wi-Fi during the conference

·         Tea Breaks

·         Accredited Certificates from the Organizing Committee

·         Best  Presentation Awards

CANCELLATION POLICY

·         Cancellations should be made in writing.

·         All cancellations or modifications of registration must be made in writing to  finance@frontiersmeetings.com

·         If Frontiers Meetings Ltd cancels this event for any indispensable reason, registered participants will be credited with the full amount paid at the time of registration. You may also use this credit for another Frontiers Meetings Ltd event(s) which must occur within ONE YEAR from the date of cancellation.

·         This cancellation policy was last updated on January 04, 2019

Note: Register yourself before early bird date to avail the discounts. For more details please contact: dementia@frontiermeetings.com

Dementia 2020: Call for Abstract

Submit your abstract for presenting your research at Dementia and Alzheimer’s 2020, scheduled during June 08-11, 2020.

Submit as per below research topics: https://frontiersmeetings.com/conferences/dementia/abstract-submission

Research Topics:

1.      Mental health & Psychiatry

2.      Dementia

3.      Care Practice and Awareness

4.      Childhood Trauma and Dementia

5.      Alzheimer’s Disease Imaging

6.      Causes and Prevention of Alzheimer’s

7.      Alzheimer’s Disease Diagnosis and Symptoms

8.      Alzheimer’s Disease Pathophysiology and Disease Mechanisms

9.      Neurodegenerative Diseases

10.  Vascular Dementia

11.  Dementia Nursing

12.  Dementia Care and Consulting

13.  Alzheimer’s Clinical Trials and Studies

14.  Brain Diseases

15.  Parkinson’s  Disease

16.  Molecular Genetics and Biology of Dementia

17.  Medical Biotechnology and Alzheimer’s disease

18.  Therapeutic Targets and mechanisms for Treatment

19.  Animal Models and Translational Medicine

            20.  Recent Studies and Case Reports

GUIDELINES

ABSTRACT STRUCTURE

·       Abstracts should be no longer than one A4 page in portrait layout.

·       The title of the abstract should be as concise as possible and should appear in bold, sentence cased and centered.

·       Co-authors and affiliations below the title should be in Italics (the main author's name should be underlined, and the name of the presenting author should be marked with an asterisk (*).

·       The abstract must be written in the most preferable language, i.e. English and content should have a maximum character of 300 words.

·       The main body of the abstract should be in Times New Roman, Font size 12, Justified, Line spacing 1.5.

·       References, denoted by superscript numbers in the text should be listed at the end of the text using standard Chemical Abstracts Source Service Index terminology followed by YEAR, VOLUME and PAGE.

·       The use of figures, graphs, and schemes are recommended where this aids the understanding of the text.

·       Abstracts should be submitted as in MS Word or PDF format, either via email attachment to conference email with the subject line 'conference name abstract' or online submission method via the conference website. 

·       Please include the full details of the main author and the presenting author in the email and indicate whether you are submitting an Oral or a Poster Presentation.

·       Note: There is a 1 MB limit for online abstract submission if your abstract is larger than 1 MB, then you are recommended to send it via email as an attachment.

·       After completion of the conference, speakers could submit their full-length papers to any of our related journals and it will be published within 2 months of the time period with additional charges.

·       A confirmation mail will be sent in regards to receiving your abstract, and if the submitter does not receive any mail within next 24 Hrs, he/she is suggested to the contact the respective conference coordinator, manager or ambassador.

We firmly believe that ethical conduct is the most essential virtual of any academic, hence any act of plagiarism is totally unaccepted and academic misconduct will not be tolerated.

THE CONFERENCE OFFERS TWO OPTIONS FOR ABSTRACT SUBMISSION

OPTION-1

Suited for research conducted in all the disciplines. Check a sample abstract for this option here. Abstracts submitted under the first option should contain concise statements of:

·         Backgrounds: Indicate the purpose and objective of the research, the hypothesis that was tested or a description of the problem being analyzed or evaluated.

·         Methods: Describe (the study period/ setting/location, study design, study population, data collection and methods of analysis used.

·         Results: Present as clearly and in as much detail as possible the findings/outcome of the study. Please summarize any specific results.

·         Conclusions: Explain the significance of your findings/outcomes of the study of HIV prevention, treatment, care and/or support, and Future Implications of the results.

The following review criteria will be used in scrolling abstracts submitted under OPTION 1:

·         Is there a clear background and Justified objective?

·         Is the methodology/study design appropriate for the objectives?

·         Are the results important and clearly presented?

·         Are the conclusions supported by the results?

·         Is the study original, and does it contribute to the field?

OPTION-2

Suited for research conducted in all disciplines. Check a sample abstract for this option here. Abstracts submitted under the first option should contain concise statements of:

·         Backgrounds: Summarize the purpose, scope, and objectives, of the program, project or policy.

·         Methods: Describe the programme, project or policy period/ setting/location, the structure, key population (if applicable), activities and interventions were undertaken in support of the program, project or policy.

·         Lessons Learned: Present as clearly and in as much detail as possible the methods/findings/ outcomes of the program, project or policy; include analytic approaches, evaluation of lessons learned and best practices with a succinct description of the methods used, in addition, please summarize any specific results that specifically support your conclusions of lessons learned and best practices.

·         Conclusions: Explain the significance of the methods used and findings/outcomes of the program, project or policy for HIV prevention, treatment, care and /or support, and future implications of the results.

PEER-REVIEW PROCESS:

All submitted abstracts will go through a peer-review process carried out by a peer review committee. After the successful review of your abstract, we will guide you further steps towards your presence at our event.